Lecture 8: Protein Sorting: Organelle Biogenesis and Protein Secretion
17.3 The rough ER is an extensive interconnected series of flattened sacs
17.3 Secretory proteins are found in the ER lumen immediately after synthesis
17.3 Overview of the secretory pathway
Secretory Animation
17.4 Two proteins initiate the interaction of signal sequences with the ER membrane
Translocation Animation (secretory proteins)
17.4 Structure of the signal recognition particle (SRP)
17.4 Polypeptides move through the translocon into the ER lumen
17.4 GTP hydrolysis powers protein transport into the ER in mammalian cells
17.5 Topologies of some integral membrane proteins synthesized on the rough ER
17.5 Most nominal cytosolic transmembrane proteins have an N-terminal signal sequence and an internal topogenic sequence
17.5 A single internal topogenic sequence directs insertion of some single-pass transmembrane proteins
17.5 Multipass transmembrane proteins have multiple topogenic sequences
Translocation Animation (integral proteins)
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