Lecture 22: Cancer
Cancer
PPT Slide
24.1 Benign tumors arise with great frequency but pose little risk because they are localized and small
24.1 Malignant tumors generally invade surrounding tissue and spread throughout the body
24.1 DNA from tumor cells can transform normal cultured cells
24.1 Epidemiology of human cancers indicates that development of cancer requires several mutations
24.1 The development of colon cancer is characterized by a well-ordered series of mutations
24.1 Overexpression of multiple oncogenes increases tumor formation
24.1 Cancers originate in proliferating cells
24.2 Proto-oncogenes and tumor-suppressor genes: the seven types of proteins that participate in controlling cell growth
24.2 Gain-of-function mutations convert proto-oncogenes into oncogenes
24.3 Inappropriate expression of nuclear transcription factors can induce transformation
24.4 Loss of TGF? signaling contributes to abnormal cell proliferation and malignancy
Cell to Cell Signaling
20.1 Cell-to-cell communication by extracellular signaling usually involves six steps
Email: Brianb@muskingum.edu
Home Page: http://muskingum.edu/~brianb/Cellphys/Cellphys.html